SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription.

Supplementary Information SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription

Nuclear microbiology--bacterial assault on the nucleolus.

Intracellular bacterial pathogens exploit the compartmentalization of the eukaryotic cell to create an environment that supports their own survival and growth. Among cellular organelles, the nucleus has long been considered to be mostly ‘safe’ from direct bacterial attacks. However, a growing number of molecules secreted by bacteria—termed ‘nucleomodulins’—target this central organelle to subve...

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

The intracellular bacterial pathogen Legionella pneumophila causes an inflammatory pneumonia called Legionnaires' Disease. For virulence, L. pneumophila requires a Dot/Icm type IV secretion system that translocates bacterial effectors to the host cytosol. L. pneumophila lacking the Dot/Icm system is recognized by Toll-like receptors (TLRs), leading to a canonical NF-κB-dependent transcriptional...

The roles of EPIYA sequence to perturb the cellular signaling pathways and cancer risk

Abstract It was shown that several pathogenic bacterial effector proteins contain the Glu-Pro-Ile-Tyr-Ala (EPIYA) or a similar sequence. These bacterial EPIYA effectors are delivered into host cell via type III or IV secretion system, where they undergo tyrosine phosphorylation at the EPIYA sequences, which triggers interaction with multiple host cell SH2 domain-containing proteins and thereby...

A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors

Defense against pathogens in multicellular eukaryotes depends on intracellular immune receptors, yet surveillance by these receptors is poorly understood. Several plant nucleotide-binding, leucine-rich repeat (NB-LRR) immune receptors carry fusions with other protein domains. The Arabidopsis RRS1-R NB-LRR protein carries a C-terminal WRKY DNA binding domain and forms a receptor complex with RPS...